tert-butyl N'-[5-chloro-2-(4-fluorophenyl)-2-methoxypentanoyl]hydrazinecarboxylate → 5-Chloro-2-(4-fluorophenyl)-2-methoxyvaleric acid hydrazide monohydrochloride

HRID 2235744Notes

Reaction equation

HRID 2235744 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][C:5]([C:19]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=1)([O:17][CH3:18])[C:6]([NH:8][NH:9]C(OC(C)(C)C)=O)=[O:7]>Cl.O1CCOCC1>[ClH:1].[Cl:1][CH2:2][CH2:3][CH2:4][C:5]([C:19]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=1)([O:17][CH3:18])[C:6]([NH:8][NH2:9])=[O:7]

Participants

4

Reactant 1

HCID 67067169tert-butyl N'-[5-chloro-2-(4-fluorophenyl)-2-methoxypentanoyl]hydrazinecarboxylate

Product 1

HCID 670671765-Chloro-2-(4-fluorophenyl)-2-methoxyvaleric acid hydrazide monohydrochlorideYield 216.8%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl N′-[5-chloro-2-(4-fluorophenyl)-2-methoxypentanoyl]hydrazinecarboxylate (90 mg) was dissolved in a solution of 4 N hydrogen chloride in dioxane (1 mL), and the reaction solution was stirred at room temperature for 70 minutes. The reaction solution was concentrated under reduced pressure to obtain 81 mg of the title compound. The property value of the compound is as follows.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-676b75cb52ea411e938b4d0dbb5974ae
Source dataset
uspto-grants-2010_05
Patent number
US07713993B2

Reaction notes

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