Diisopropylethylamine → HCID 58782529, compound

HRID 2236060Notes

Reaction equation

HRID 2236060 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]([CH2:21][CH2:22][CH2:23][N:24]2[CH2:31][CH:30]3[CH:26]([CH2:27][NH:28][CH2:29]3)[CH2:25]2)[C:10]([CH:12]2[CH2:17][CH2:16][N:15]([C:18](=[O:20])[CH3:19])[CH2:14][CH2:13]2)=[O:11])[CH:5]=[CH:6][C:7]=1[CH3:8].CCN(C(C)C)C(C)C.[Cl:41][C:42]1[CH:47]=[C:46]([F:48])[CH:45]=[CH:44][C:43]=1[S:49](Cl)(=[O:51])=[O:50]>C(Cl)Cl>[Cl:41][C:42]1[CH:47]=[C:46]([F:48])[CH:45]=[CH:44][C:43]=1[S:49]([N:28]1[CH2:29][CH:30]2[CH2:31][N:24]([CH2:23][CH2:22][CH2:21][N:9]([C:4]3[CH:5]=[CH:6][C:7]([CH3:8])=[C:2]([Cl:1])[CH:3]=3)[C:10]([CH:12]3[CH2:17][CH2:16][N:15]([C:18](=[O:20])[CH3:19])[CH2:14][CH2:13]3)=[O:11])[CH2:25][CH:26]2[CH2:27]1)(=[O:51])=[O:50]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 5228462-Chloro-4-fluorobenzene-1-sulfonyl chlorideHCID 58782555HCID 58782555, compound

Product 1

HCID 58782529HCID 58782529, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 42b (0.016 g, 0.035 mmol) and DIPEA (0.02 mL, 0.105 mmol) in DCM (1 mL) at RT was added 2-chloro-4-fluorobenzenesulfonyl chloride (104, 0.016 g, 0.07 mmol) and the mixture shaken overnight at rt. The reaction mixture was concentrated in vacuo and purified by reverse phase HPLC to afford II-296: ms (ES+) m/z 639 (M+H)+.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. custompurified by reverse phase HPLC
  3. customto afford II-296: ms (ES+) m/z 639 (M+H)+

Sources & evidence

ORD record
ord-51caa2d3b84447e39ed2d7d04caa856c
Source dataset
uspto-grants-2010_05
Patent number
US07714018B2

Reaction notes

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