反应详情

To a solution of 42b (0.016 g, 0.035 mmol) and DIPEA (0.02 mL, 0.105 mmol) in DCM (1 mL) at RT was added 2-chloro-4-fluorobenzenesulfonyl chloride (104, 0.016 g, 0.07 mmol) and the mixture shaken overnight at rt. The reaction mixture was concentrated in vacuo and purified by reverse phase HPLC to afford II-296: ms (ES+) m/z 639 (M+H)+.

1. concentrationThe reaction mixture was concentrated in vacuo
2. custompurified by reverse phase HPLC
3. customto afford II-296: ms (ES+) m/z 639 (M+H)+