Trifluoroacetic acid → HCID 59301506, compound

HRID 2236090Notes

Reaction equation

HRID 2236090 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]2[C:14]([C:27]#[N:28])=[C:15]([NH:17][C:18](=[O:26])[CH2:19][CH2:20][C:21]3O[CH:23]=[CH:24][CH:25]=3)[S:16][C:10]=2[CH2:9]1)=O)(C)(C)C.[C:29](O)([C:31](F)(F)F)=O>ClCCl>[C:27]([C:14]1[C:11]2[CH2:12][CH2:13][NH:8][CH2:9][C:10]=2[S:16][C:15]=1[NH:17][C:18](=[O:26])[CH2:19][CH2:20][C:21]1[CH:25]=[CH:24][CH:23]=[CH:31][CH:29]=1)#[N:28]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 11538611HCID 11538611, compound

Product 1

HCID 59301506HCID 59301506, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

200 mg of 3-cyano-2-(3-furan-2-yl-propanoylamino)-4,7-dihydro-5H-thieno[2,3-c]pyridine-6-carboxylic acid tert-butyl ester are dissolved in 7 ml of a mixture of dichloromethane and TFA and stirred at room temperature for 3 h. Evaporation of the solvent gives 250 mg of the desired product as TFA salt in sufficient purity for the next steps.

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-401fd7904a014c48b9c4b6835d64f3d7
Source dataset
uspto-grants-2010_05
Patent number
US07714135B2

Reaction notes

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