HCID 67536157, compound → HCID 59301332, compound

HRID 2236161Notes

Reaction equation

HRID 2236161 reaction equation
[CH3:1][O:2][CH:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][N:9]=2)[CH2:4]1>CCOC(C)=O.[Pd]>[CH3:1][O:2][CH:3]1[CH2:7][CH2:6][N:5]([C:8]2[N:9]=[CH:10][C:11]([NH2:14])=[CH:12][CH:13]=2)[CH2:4]1

Participants

4

Reactant 1

HCID 67536157HCID 67536157, compound

Product 1

HCID 59301332HCID 59301332, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

This nitro compound was dissolved in 10 mL of EtOAc, and treated with 100 mg of 10% palladium on carbon. The reaction was shaken under 50 psi of H2 overnight. The reaction was filtered through a celite pad, and the filtrate was concentrated to afford 6-(3-methoxy-pyrrolidin-1-yl)-pyridin-3-ylamine, which was used directly in the next step without further purification. LRMS calcd for C10H15N3O (m/e) 193, obsd 194 (M+H).

Workup

  1. filtrationThe reaction was filtered through a celite pad
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-a728d5dad97f4ca08f6bf5bba1ef9991
Source dataset
uspto-grants-2010_05
Patent number
US07714126B2

Reaction notes

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