2-(Tributylstannyl)furan → HCID 42625595, compound

HRID 2236478Notes

Reaction equation

HRID 2236478 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1I)[C:5]#[N:6].[O:11]1[CH:15]=[CH:14][CH:13]=[C:12]1[Sn](CCCC)(CCCC)CCCC>CN(C)C=O.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[O:11]1[CH:15]=[CH:14][CH:13]=[C:12]1[C:9]1[CH:8]=[CH:7][C:4]([C:5]#[N:6])=[CH:3][C:2]=1[OH:1]

Participants

5

Reactant 2

HCID 43936882-(Tributylstannyl)furanHCID 109446813-Hydroxy-4-iodobenzonitrile

Product 1

HCID 42625595HCID 42625595, compound

Reagents, catalysts & solvents 2

HCID 178418476HCID 178418476, compoundCatalystHCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

3-Hydroxy-4-iodo-benzonitrile (120 mg, 0.49 mmol) and PdCl2(PPh3)2 (35 mg, 0.049 mmol) and 2-furyltributyltin (200 g, 0.56 mmol) in N,N-dimethylformamide (DMF) (5 mL) is degassed and heated at 100° C. for 30 minutes (min). After the mixture cooled to room temperature, an aqueous work up is performed and the product is isolated from chromatography (80 mg, 88%).

Workup

  1. temperatureAfter the mixture cooled to room temperature
  2. customthe product is isolated from chromatography (80 mg, 88%)

Sources & evidence

ORD record
ord-08dc3834ff7143169a50ba521105203e
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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