Hydrochloric Acid → 2,2-Dimethyl-11-isopropyl-11-amino-undecanal benzylamine

HRID 223650Notes

Reaction equation

HRID 223650 reaction equation
[CH3:1][C:2]1([CH3:17])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH:5]([CH:14]([CH3:16])[CH3:15])[N:4]=[CH:3]1.Cl.[CH2:19]([NH2:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[OH-:27].[Na+]>O>[CH3:1][C:2]([CH3:17])([CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH:5]([CH:14]([CH3:16])[CH3:15])[NH2:4])[CH:3]=[O:27].[CH2:19]([NH2:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 7504BenzylamineHCID 14798Sodium HydroxideHCID 204360973,3-Dimethyl-12-isopropyl-1-aza-cyclododecene

Product 1

HCID 867378492,2-Dimethyl-11-isopropyl-11-amino-undecanal benzylamineYield 56.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The procedure described in Example 2(b) is repeated, except that 68.5 g (0.5 mol) of 3,3-dimethyl-12-isopropyl-1-aza-cyclododecene, 50 g of 37% hydrochloric acid, 54 g (0.5 mol) of benzylamine and 200 ml of water are used. After neutralisation with 22 g (0.55 mol) of solid sodium hydroxide, 97 g (0.282 mol) of 2,2-dimethyl-11-isopropyl-11-amino-undecanal-benzylamine are obtained; yield 56.4% of theory.

Sources & evidence

ORD record
ord-ee0f14f94709454c85f67d1eab9649d0
Source dataset
uspto-grants-1982_10
Patent number
US04355177

Reaction notes

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