反应详情

2-(4-Bromo-phenyl)-pyrrolidine (640 mg, 2.83 mmol) and allyl bromide (343 mg, 2.83 mmol) is mixed in THF (15 mL) and K2CO3 (390 mg, 2.83 mmol) is then added. The mixture is heated at reflux for 2 h before THF is removed under reduced pressure and the residue is partitioned between EtOAc and H2O. The EtOAc layer is dried and concentrated and the residue is then subjected to chromatography to provide the desired product (470 mg, 62.4%).

1. temperatureThe mixture is heated
2. customis removed under reduced pressure
3. customthe residue is partitioned between EtOAc and H2O
4. dry with materialThe EtOAc layer is dried
5. concentrationconcentrated