Benzenamine, 4-(4-morpholinyl)- → HCID 178518329, compound

HRID 2236586Notes

Reaction equation

HRID 2236586 reaction equation
CO[CH:3]=[C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7](=[O:14])[NH:6][C:5]1=[O:15].[N:16]1([C:22]2[CH:27]=[CH:26][C:25]([NH2:28])=[CH:24][CH:23]=2)[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>CN(C)C=O>[N:16]1([C:22]2[CH:23]=[CH:24][C:25]([NH:28]/[CH:3]=[C:4]3\[C:5](=[O:15])[NH:6][C:7](=[O:14])[C:8]4[C:13]\3=[CH:12][CH:11]=[CH:10][CH:9]=4)=[CH:26][CH:27]=2)[CH2:17][CH2:18][O:19][CH2:20][CH2:21]1

Participants

4

Reactant 2

HCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 686923374-Methoxymethylene-4H-isoquinoline-1,3-dione

Product 1

HCID 178518329HCID 178518329, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 4-methoxymethylene-4H-isoquinoline-1,3-dione (101.5 mg, 0.5 mmol), 4-morpholin-4-yl-phenylamine (89.12 mg, 0.5 mmol) in 1 mL of N,N-dimethylformamide is heated at 110° C. for 1 h. After cooling in the refrigerator, the precipitate is collected, and washed with ether to give 139 mg (80%) of greenish yellow solid mp 257-258° C.; MS (ESI) m/z 350.17 (M+1); Analysis for C20H19N3O3: Calcd: C, 68.75; H, 5.48; N, 12.03. Found: C, 68.49; H, 5.57; N, 11.90.

Workup

  1. temperatureAfter cooling in the refrigerator
  2. customthe precipitate is collected
  3. washwashed with ether

Sources & evidence

ORD record
ord-8b99760200f645f285c56bb2429f87d8
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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