1H-Indazol-6-amine → HCID 178518310, compound

HRID 2236587Notes

Reaction equation

HRID 2236587 reaction equation
CO[CH:3]=[C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7](=[O:14])[NH:6][C:5]1=[O:15].[NH:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([NH2:25])[CH:23]=2)[CH:18]=[N:17]1>CN(C)C=O>[NH:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([NH:25]/[CH:3]=[C:4]3\[C:5](=[O:15])[NH:6][C:7](=[O:14])[C:8]4[C:13]\3=[CH:12][CH:11]=[CH:10][CH:9]=4)[CH:23]=2)[CH:18]=[N:17]1

Participants

4

Reactant 2

HCID 814231H-Indazol-6-amineHCID 686923374-Methoxymethylene-4H-isoquinoline-1,3-dione

Product 1

HCID 178518310HCID 178518310, compoundYield 52.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 4-methoxymethylene-4H-isoquinoline-1,3-dione (101.5 mg, 0.5 mmol), 1H-indazol-6-ylamine (66.6 mg, 0.5 mmol) in 1 mL of N,N-dimethylformamide is heated at 110° C. for 1 h. After cooling in the refrigerator, the precipitate is collected, and washed with ether to give 79.4 mg (52%) of yellow solid mp >300° C.; MS (ESI) m/z 305.10 (M+1);

Workup

  1. temperatureAfter cooling in the refrigerator
  2. customthe precipitate is collected
  3. washwashed with ether

Sources & evidence

ORD record
ord-10604299247449e485c408bf4bde0d70
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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