反应详情

A mixture of 5-aminomethyl-2-methoxy-phenol hydrochloride (145 mg, 0.50 mmole), 4 mL of N,N-dimethylformamide and triethylamine (75 □L, 0.54 mmole) is stirred for 15 minutes. Then (4E)-6-methoxy-4-methoxymethylene-4H-isoquinoline-1,3-dione (117 mg, 0.50 mmole) is added and the reaction mixture stirred for one hour. The reaction mixture is diluted with ether, filtered washed with water, washed with ether and dried to give an light beige solid, 161 mg, (91%), mp 240-2° C. dec; MS (ESI): m/z 355.2 (M−H).

1. stirringthe reaction mixture stirred for one hour
2. filtrationfiltered
3. washwashed with water
4. washwashed with ether
5. customdried
6. customto give an light beige solid, 161 mg, (91%), mp 240-2° C. dec