反应详情

According to the general procedure of example 129, an amount of 100 mg (0.55 mmol) of 5-(aminomethyl)-2-propoxyphenol is dissolved in N,N-dimethylformamide (5 mL). 228 μl (1.65 mmol) of triethylamine is added followed by 171 mg (0.607 mmol) of (4E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione. After the mixture is stirred at room temperature for 30 min, water (3 mL) is added and the reaction mixture is stirred for 3 hours. The precipitate is filtered and washed several times with anhydrous ether. The crude solid is then purified by high performance liquid chromatography to give 67 mg of a white solid. MS (ESI) m/z 430.8 (M+1).

1. stirringthe reaction mixture is stirred for 3 hours
2. filtrationThe precipitate is filtered
3. washwashed several times with anhydrous ether
4. customThe crude solid is then purified by high performance liquid chromatography