反应详情

温度

70 °C

To a solution of (4Z)-6-bromo-4-{[(3,4-dihydroxybenzyl)-amino]methylene}isoquinoline-1,3(2H,4H)-dione (0.74 g, 1.9 mmol) in 5 mL of N,N′-dimethylformamide is added 2-iodopropane (0.19 mL, 1.9 mmol) and 0.52 g (3.8 mmol) of potassium carbonate. The reaction mixture is heated at 70° C. under N2. Mass spectroscopy indicated the completion of reaction after 3.5 h. The reaction mixture is filtered through a pad of celite, and water is added to give a precipitate. It is filtered and washed successively with MeOH, Et2O and hexane, dried in oven (60° C.) overnight to afford 0.58 g (70.7% yield) of tan solid: mp 212-213° C.; MS (ESI) m/z 431.2 and 433.2 (M+H)+1

1. customthe completion of reaction after 3.5 h
2. filtrationThe reaction mixture is filtered through a pad of celite, and water
3. additionis added
4. customto give a precipitate
5. filtrationIt is filtered
6. washwashed successively with MeOH, Et2O and hexane
7. customdried in oven (60° C.) overnight