反应详情

An amount of (4E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione (0.40 g, 1.42 mmol) in 5 mL of N,N′-dimethylformamide is added 5-(aminomethyl)-2-(2-methoxyethoxy)phenol (0.33 g, 1.70 mmol) and 0.44 mL (4.26 mmol) of triethylamine. The reaction mixture is heated at room temperature overnight under N2. Mass spectroscopy suggested the completion of reaction. Reaction mixture is subsequently evaporated under high-pressure vacuum to brown solid. The solid is stirred in 5 mL of methanol for 10 min, then filtered, and washed in turn with 100 mL of water, 100 mL of methanol, and ether and hexane to afford 0.48 g (76.2% yield) of tan solid: mp 179-180° C.; MS (ESI) m/z 447.0-449.0 (M+H)+1

1. customthe completion of reaction
2. customReaction mixture
3. customis subsequently evaporated under high-pressure vacuum to brown solid
4. filtrationfiltered
5. washwashed in turn with 100 mL of water, 100 mL of methanol, and ether and hexane