反应详情

An amount of 5-(aminomethyl)-2-propoxyphenol (60 mg, 0.33 mmol) is dissolved in N,N-dimethylformamide (2 mL). 0.137 m/(1.0 mmol) of triethylamine is added followed by 100 mg (0.30 mmol) of (4E)-6-iodo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione. After the mixture is stirred at room temperature for 30 min, water (5 mL) is added and the reaction mixture is stirred for 60 min. The precipitate is filtered and washed several times with anhydrous ether. The crude solid is then purified by high performance liquid chromatography to give 54 mg of a white solid. MS (ESI) m/z 480.3 (M+1).

1. stirringthe reaction mixture is stirred for 60 min
2. filtrationThe precipitate is filtered
3. washwashed several times with anhydrous ether
4. customThe crude solid is then purified by high performance liquid chromatography