反应详情

A mixture of (Z)-6-bromo-4-((3,4-dihydroxybenzylamino)methylene)isoquinoline-1,3(2H,4H)-dione (195 mg, 0.50 mmole), dimethylformamide (5 mL), potassium carbonate (415 mg, 3.0 mmole) and diethyl 2,2-dibromomalonate (159 mg, 0.50 mmole) is stirred at room temperature overnight. The reaction mixture is filtered and washed with dimethylformamide, the filtrate is evaporated dissolved in 2% methanol in chloroform and passed through a pad of Florisil. The eluate is evaporated to give a beige solid, 114 mg, (41%), mp 222-3° C.; MS (ES+): m/z 545.1 (M+H).

1. filtrationThe reaction mixture is filtered
2. washwashed with dimethylformamide
3. customthe filtrate is evaporated
4. dissolutiondissolved in 2% methanol in chloroform
5. customThe eluate is evaporated
6. customto give a beige solid, 114 mg, (41%), mp 222-3° C.