反应详情

A mixture of 4-{[(5-Amino-4-hydroxy-pyridin-2-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione (334 mg, 0.766 mmole), 20 mL of dimethylacetamide is stirred, acryoyl chloride (651 uL, 7.66 mmole) is added and the reaction mixture stirred for one hour. The reaction mixture is evaporated to dryness, stirred overnight with a saturated aqueous sodium bicarbonate solution, filtered, washed well with water, and dried to give a green solid, 98 mg, (27%); MS (ES−): m/z 489 (M−H).

1. stirringthe reaction mixture stirred for one hour
2. customThe reaction mixture is evaporated to dryness
3. stirringstirred overnight with a saturated aqueous sodium bicarbonate solution
4. filtrationfiltered
5. washwashed well with water
6. customdried
7. customto give a green solid, 98 mg, (27%)