tert-Butoxy bis(dimethylamino)methane → HCID 74828433, compound

HRID 2236887Notes

Reaction equation

HRID 2236887 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([N:6]2[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][C:7]2=[O:13])=[CH:2]1.C(O[CH:19](N(C)C)[N:20]([CH3:22])[CH3:21])(C)(C)C>CN(C)C=O>[CH3:19][N:20]([CH3:22])[CH:21]=[CH:12][C:9]1[CH:10]=[CH:11][N:6]([C:3]2[CH:4]=[CH:5][O:1][CH:2]=2)[C:7](=[O:13])[CH:8]=1

Participants

4

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 426257441-(3-Furanyl)-4-methyl-2(1H)-pyridinone

Product 1

HCID 74828433HCID 74828433, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
150 °C

Procedure

A mixture of 1-furan-3-yl-4-methyl-1H-pyridin-2-one (3.7 g, 21 mmol), tert-butoxybis(dimethylamino)methane (11 g, 63 mmol), and N,N-dimethylformamide (4 mL) is heated in a 150° C. oil bath for 2½ hours and then concentrated to dryness under reduced pressure. A quantitative yield of 4-(2-dimethylamino-vinyl)-1-furan-3-yl-1H-pyridin-2-one is assumed, and the material is carried on without further purification.

Workup

  1. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-aa02f9eba6284554836aa904a4ef6aa0
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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