Acetic Acid → HCID 70541530, compound

HRID 223692Notes

Reaction equation

HRID 223692 reaction equation
C(OC([NH:8][C@H:9]([C:14]([NH:16][C@H:17]([C:21]([NH:23][C@H:24]([C:35]([OH:37])=[O:36])[CH2:25][C:26]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[NH:28][CH:27]=1)=[O:22])[CH:18]([CH3:20])[CH3:19])=[O:15])[CH2:10][CH2:11][S:12][CH3:13])=O)(C)(C)C.C(O)(=O)C.[ClH:42].O>O1CCOCC1>[ClH:42].[NH2:8][C@H:9]([C:14]([NH:16][C@H:17]([C:21]([NH:23][C@H:24]([C:35]([OH:37])=[O:36])[CH2:25][C:26]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[NH:28][CH:27]=1)=[O:22])[CH:18]([CH3:19])[CH3:20])=[O:15])[CH2:10][CH2:11][S:12][CH3:13]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 962WaterHCID 53688324HCID 53688324, compound

Product 1

HCID 70541530HCID 70541530, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound was prepared using the previously described procedure and the following reagants: t-butyl oxycarbonyl-methionyl-valyl-tryptophan (4.61 grams), 32 milliliters of glacial acetic acid and 17.5 ml (106.2 mmoles) 6.07 N hydrochloric acid in dioxane. Yield is 3.2 grams. Analysis calculated for C21H30N4O4S.HCL.H2O: C, 51.57; H, 6.80; N, 11.46. Found: C, 51.29; H, 6.59; N,-11.72.

Sources & evidence

ORD record
ord-3fe4852ccf014553b9591cea2df7e8d4
Source dataset
uspto-grants-1982_10
Patent number
US04356118

Reaction notes

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