Acetic Acid → HCID 70542448, compound

HRID 223694Notes

Reaction equation

HRID 223694 reaction equation
C(OC([NH:8][C@H:9]([C:14]([NH:16][C@H:17]([C:21]([NH:23][C@H:24]([C:35]([OH:37])=[O:36])[CH2:25][C:26]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[NH:28][CH:27]=1)=[O:22])[CH:18]([CH3:20])[CH3:19])=[O:15])[C@H:10]([CH2:12][CH3:13])[CH3:11])=O)(C)(C)C.C(O)(=O)C.[ClH:42].O>O1CCOCC1>[ClH:42].[NH2:8][C@H:9]([C:14]([NH:16][C@H:17]([C:21]([NH:23][C@H:24]([C:35]([OH:37])=[O:36])[CH2:25][C:26]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[NH:28][CH:27]=1)=[O:22])[CH:18]([CH3:20])[CH3:19])=[O:15])[C@H:10]([CH2:12][CH3:13])[CH3:11]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 962WaterHCID 53933398HCID 53933398, compound

Product 1

HCID 70542448HCID 70542448, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound is prepared using the previously described procedures and the following reagants: 1.17 g (2.3 mmoles) t-butyloxycarbonyl-isoleucyl-valyl-tryptophan, 10 ml glacial acetic acid and 10 ml 6.07 HCl in dioxane. Total yield was 0.91 g. (88 percent). Analysis calculated for C22H32N4O4.HCl. H2O: C, 56.10; H, 7.49, N, 11.90. Found: C, 56.34; H, 7.48; N, 11.72.

Sources & evidence

ORD record
ord-86b55e511d5e46388fc0da42439c617f
Source dataset
uspto-grants-1982_10
Patent number
US04356118

Reaction notes

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