反应详情

In a flask equipped with a water separator are placed 7 g of 2-pyridyl acetonitrile, 12.8 g of isobutyraldehyde, 0.9 ml of acetic acid, 0.18 ml of piperidine and 250 ml of dry benzene. The mixture is heated under reflux for 3 hours. After cooling, the reaction mixture is washed with water, the organic phase is dried over sodium sulfate then the solvent is evaporated to dryness.

1. temperatureThe mixture is heated
2. temperatureunder reflux for 3 hours
3. temperatureAfter cooling
4. washthe reaction mixture is washed with water
5. dry with materialthe organic phase is dried over sodium sulfate
6. customthe solvent is evaporated to dryness