7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine → HCID 86605196, compound

HRID 2237402Notes

Reaction equation

HRID 2237402 reaction equation
[CH2:1]([NH:8][C:9]1[N:18]=[C:17]2[C:12]([C:13]([N:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)=[N:14][C:15]([N:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)=[N:16]2)=[N:11][C:10]=1[Cl:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:31](=[O:34])([O-])[OH:32].[Na+]>O1CCCC1>[CH2:1]([NH:8][C:9]1[N:18]=[C:17]2[C:12]([C:13]([N:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)=[N:14][C:15]([N:19]3[CH2:20][CH2:21][N:22]([C:31]([O:32][C:2]([CH3:7])([CH3:3])[CH3:1])=[O:34])[CH2:23][CH2:24]3)=[N:16]2)=[N:11][C:10]=1[Cl:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 1306047-Benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridineHCID 516892Sodium Bicarbonate

Product 1

HCID 86605196HCID 86605196, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.02 g (2.40 mmol) 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine are placed in 10 ml of tetrahydrofuran, 1.05 g (4.80 mmol) BOC-anhydride and 5 ml saturated sodium hydrogen carbonate solution are added. The mixture is stirred for 1.5 hours at ambient temperature, then evaporated down in vacuo. The aqueous residue is diluted with water, the precipitate is suction filtered, washed and dried.

Workup

  1. customevaporated down in vacuo
  2. additionThe aqueous residue is diluted with water
  3. filtrationfiltered
  4. washwashed
  5. customdried

Sources & evidence

ORD record
ord-b6a43f692b1a46f0a360e735e5821549
Source dataset
uspto-grants-2010_05
Patent number
US07718654B2

Reaction notes

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