Chloroform → HCID 68470337, compound

HRID 2237443Notes

Reaction equation

HRID 2237443 reaction equation
C(OC([C:6]1[S:20][C:9]2[CH2:10][CH2:11][N:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:13][CH2:14][C:8]=2[C:7]=1[O:21][CH3:22])=O)C.C(Cl)(Cl)Cl.[Br:27]N1C(=O)CCC1=O.C(=O)(O)[O-].[Na+]>C(O)(=O)C>[CH2:18]([O:17][C:15]([N:12]1[CH2:13][CH2:14][C:8]2[C:7]([O:21][CH3:22])=[C:6]([Br:27])[S:20][C:9]=2[CH2:10][CH2:11]1)=[O:16])[CH3:19]

Participants

6

Reactant 4

HCID 6212ChloroformHCID 67184N-bromobutanimideHCID 516892Sodium BicarbonateHCID 59302561HCID 59302561, compound

Product 1

HCID 68470337HCID 68470337, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The product of step c) (17 mg, 0.067 mmol) was dissolved in 1 mL 1:1 acetic acid:CHCl3 and treated with N-bromosuccinimide (12 mg, 0.068 mmol). After 30. minutes, the reaction solution was added dropwise to a solution of saturated sodium bicarbonate and extracted with ethyl acetate. The organic extracts were concentrated to give the subtitle compound, which was used without further purification.

Workup

  1. extractionextracted with ethyl acetate
  2. concentrationThe organic extracts were concentrated

Sources & evidence

ORD record
ord-b37710babdc64f49a6a32a626e04153c
Source dataset
uspto-grants-2010_05
Patent number
US07718647B2

Reaction notes

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