Hydrochloric Acid → 3-[1-(4-chlorophenyl)-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl]-N-methylpropan-1-amine hydrochloride

HRID 2237476Notes

Reaction equation

HRID 2237476 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[CH2:11][N:10]([CH2:18][CH2:19][CH2:20]Cl)[S:9]2(=[O:23])=[O:22])=[CH:4][CH:3]=1.[CH3:24][NH2:25].Cl>>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[CH2:11][N:10]([CH2:18][CH2:19][CH2:20][NH:25][CH3:24])[S:9]2(=[O:23])=[O:22])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 685822151-(4-chlorophenyl)-3-(3-chloropropyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide

Product 1

HCID 685837113-[1-(4-chlorophenyl)-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl]-N-methylpropan-1-amine hydrochloride

Procedure

In an analogous manner to Example 1, step 8, 1-(4-chlorophenyl)-3-(3-chloropropyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (27 mg) was reacted with methylamine and then treated with HCl to provide 3-[1-(4-chlorophenyl)-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl]-N-methylpropan-1-amine hydrochloride (24 mg):

Sources & evidence

ORD record
ord-3194fa2d2db64dd1986f6376266ac722
Source dataset
uspto-grants-2010_05
Patent number
US07718652B2

Reaction notes

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