Hydrochloric Acid → HCID 68582538, compound

HRID 2237478Notes

Reaction equation

HRID 2237478 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[CH2:12][N:11]([CH2:19][CH2:20][CH2:21]Cl)[S:10]2(=[O:24])=[O:23])[CH:5]=[CH:6][C:7]=1[F:8].[CH3:25][NH2:26].Cl>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[CH2:12][N:11]([CH2:19][CH2:20][CH2:21][NH:26][CH3:25])[S:10]2(=[O:23])=[O:24])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 68581305HCID 68581305, compound

Product 1

HCID 68582538HCID 68582538, compound

Procedure

In an analogous manner to Example 1, step 8, 1-(3-chloro-4-fluorophenyl)-3-(3-chloropropyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (73 mg) was reacted with methylamine and then treated with HCl to provide 3-[1-(3-chloro-4-fluorophenyl)-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl]-N-methylpropan-1-amine hydrochloride (61 mg):

Sources & evidence

ORD record
ord-4e61f8a019794b2aa953c97901b649f6
Source dataset
uspto-grants-2010_05
Patent number
US07718652B2

Reaction notes

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