Hydrochloric Acid → HCID 44248102, compound

HRID 2237482Notes

Reaction equation

HRID 2237482 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[N:7]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)[S:6]1(=[O:23])=[O:22].[CH3:24][NH2:25].Cl>>[ClH:1].[CH3:24][NH:25][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[N:7]([C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)[S:6]1(=[O:23])=[O:22]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 44249490HCID 44249490, compound

Product 1

HCID 44248102HCID 44248102, compound

Procedure

In an analogous manner to Example 1, step 8, 3-(3-chloropropyl)-1-(4-methylphenyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (81 mg) was reacted with methylamine and then treated with HCl to provide N-methyl-3-[1-(4-methylphenyl)-2,2-dioxido-1,4-dihydro-3H-2,1,3-benzothiadiazin-3-yl]propan-1-amine hydrochloride (61 mg):

Sources & evidence

ORD record
ord-484f5f8e938741a3aea2fa28c3cd3f25
Source dataset
uspto-grants-2010_05
Patent number
US07718652B2

Reaction notes

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