Hydrochloric Acid → HCID 178496547, compound

HRID 2237742Notes

Reaction equation

HRID 2237742 reaction equation
C[O:2][C:3](=[O:15])[C:4]([C@H:7]1[CH2:12][CH2:11][C@@H:10]([O:13][CH3:14])[CH2:9][CH2:8]1)([CH3:6])[CH3:5].[OH-].[Li+].Cl>CO>[CH3:14][O:13][C@@H:10]1[CH2:11][CH2:12][C@H:7]([C:4]([CH3:6])([CH3:5])[C:3]([OH:15])=[O:2])[CH2:8][CH2:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 178500378HCID 178500378, compound

Product 1

HCID 178496547HCID 178496547, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.200 g of 2-(cis-4-methoxy-cyclohexyl)-2-methyl-propionic acid methyl ester are dissolved in 4 ml of methanol. 4 ml of a 1M aqueous lithium hydroxide solution is added and the mixture is stirred for 16 hours at room temperature. The reaction mixture is then neutralised with 1M HCl and concentrated under reduced pressure. The title compound is identified from the residue by means of flash chromatography (SiO2 60F) based on its Rf value.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-8d577335d3a942fab8f2115a60706dfb
Source dataset
uspto-grants-2010_05
Patent number
US07718675B2

Reaction notes

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