Hydrochloric Acid → HCID 66889123, compound

HRID 2237746Notes

Reaction equation

HRID 2237746 reaction equation
C([O:3][C:4](=[O:15])[C:5]([C@H:8]1[CH2:13][CH2:12][CH2:11][C@@H:10]([OH:14])[CH2:9]1)([CH3:7])[CH3:6])C.[OH-].[Li+].Cl>CO>[OH:14][C@H:10]1[CH2:11][CH2:12][CH2:13][C@@H:8]([C:5]([CH3:7])([CH3:6])[C:4]([OH:15])=[O:3])[CH2:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 68575979HCID 68575979, compound

Product 1

HCID 66889123HCID 66889123, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.00 g of 2-(cis-3-hydroxy-cyclohexyl)-2-methyl-propionic acid ethyl ester are dissolved in 30 ml of methanol. 30 ml of a 1M aqueous lithium hydroxide solution are added and the mixture is stirred for 16 hours at room temperature. The reaction mixture is neutralised with 1M HCl and concentrated by evaporation. The title compound is identified from the residue by means of flash chromatography (SiO2 60F) based on its Rf value.

Workup

  1. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-f54ccb0936fd4e4c95caa4aec19c7731
Source dataset
uspto-grants-2010_05
Patent number
US07718675B2

Reaction notes

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