Isoamyl Nitrite → 3-Methyl-4-(trifluoromethyl)benzonitrile
Reaction equation
N[C:2]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[C:7]([CH3:14])=[CH:6][C:3]=1[C:4]#[N:5].N(OCCC(C)C)=O>C1COCC1.CC(OC)(C)C>[CH3:14][C:7]1[CH:6]=[C:3]([CH:2]=[CH:9][C:8]=1[C:10]([F:11])([F:12])[F:13])[C:4]#[N:5]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 23 °C
Procedure
To a solution of 2-amino-5-methyl-4-trifluoromethyl-benzonitrile from step 4 (23.34 g, 117 mmol) in dry THF (350 mL) was added isoamyl nitrite (34.3 mL, 257 mmol), and the mixture was refluxed for 20 h. Additional isoamyl nitrite (16.6 mL, 129 mmol) was added and the mixture was refluxed for further 20 h. The mixture was cooled to 23° C. and diluted with TBME, the organic layer was washed with 1 N HCl, sat. NaHCO3-sol. and brine, dried over Na2SO4.
Workup
- temperaturethe mixture was refluxed for 20 h
- temperaturethe mixture was refluxed for further 20 h
- washthe organic layer was washed with 1 N HCl, sat. NaHCO3-sol
- dry with materialand brine, dried over Na2SO4
Sources & evidence
- ORD record
- ord-e56b7863b86548488d8d1ccc8a934bb0
- Source dataset
- uspto-grants-2010_05
- Patent number
- US07718661B2
Reaction notes
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