Ammonium Hydroxide → 2-Chloro-1,3-thiazole-5-sulfonamide

HRID 2237800Notes

Reaction equation

HRID 2237800 reaction equation
[Cl:1][C:2]1[S:3][C:4]([S:7](Cl)(=[O:9])=[O:8])=[CH:5][N:6]=1.[NH4+:11].[OH-]>CCN(CC)CC>[Cl:1][C:2]1[S:3][C:4]([S:7]([NH2:11])(=[O:9])=[O:8])=[CH:5][N:6]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 162289432-Chloro-1,3-thiazole-5-sulfonyl chloride

Product 1

HCID 220195182-Chloro-1,3-thiazole-5-sulfonamideYield 61.4%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Prepared by general procedure III from 2-Chloro-thiazole-5-sulfonyl chloride (1.1 g, 5 mmol) and NH4OH (0.42 mL, 6 mmol) with Et3N (0.77 mL, 6 mmol to give the title compound as a light-brown solid (610 mg, 61%). MS (ISN) 197[(M−H)−].

Sources & evidence

ORD record
ord-cd3fa97deec248c5b1a0e6be72c4e599
Source dataset
uspto-grants-2010_05
Patent number
US07718661B2

Reaction notes

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