3-(Bromomethyl)quinolin-2(1H)-one → Carbostyril malonate

HRID 2238566Notes

Reaction equation

HRID 2238566 reaction equation
BrC[C:3]1[C:4](=[O:13])[NH:5][C:6]2[C:11]([CH:12]=1)=[CH:10][CH:9]=[CH:8][CH:7]=2.[C:14]([OH:20])(=[O:19])[CH2:15][C:16]([OH:18])=[O:17].C(C(CC)C(N)=O)C.[O-]CC.[Na+]>>[C:14]([OH:20])(=[O:19])[CH2:15][C:16]([OH:18])=[O:17].[NH:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH:12]=[CH:3][C:4]1=[O:13]

Participants

4

Reactant 3

HCID 3367063-(Bromomethyl)quinolin-2(1H)-oneHCID 2723922Sodium ethoxideHCID 22466969Diethyl acetamide malonate

Product 1

HCID 68583663Carbostyril malonate

Procedure

bromomethyl carbostyril (2) is reacted with diethylacetamide malonate (3) in the presence of a base such as sodium ethoxide to give carbostyril malonate compound (4);

Sources & evidence

ORD record
ord-34d9b3f7dcba4af4b2ee6d3d51ca181d
Source dataset
uspto-grants-2010_05
Patent number
US07718805B2

Reaction notes

Loading…