HCID 68574455, compound → HCID 68574581, compound

HRID 2239310Notes

Reaction equation

HRID 2239310 reaction equation
[CH3:1][N:2]([CH3:30])[C:3]([C:5]1[CH:6]=[C:7]([O:22]CC2C=CC=CC=2)[C:8]2[N:12]=[C:11]([CH3:13])[N:10]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[C:9]=2[CH:21]=1)=[O:4]>[OH-].[Pd+2].[OH-]>[CH3:30][N:2]([CH3:1])[C:3]([C:5]1[CH:6]=[C:7]([OH:22])[C:8]2[N:12]=[C:11]([CH3:13])[N:10]([C:14]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:15])[C:9]=2[CH:21]=1)=[O:4]

Participants

3

Reactant 1

HCID 68574455HCID 68574455, compound

Product 1

HCID 68574581HCID 68574581, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

The title compound was prepared as a white solid in 92% yield (4.10 g) from 1,1-dimethylethyl 6-[(dimethylamino)carbonyl]-2-methyl-4-[(phenylmethyl)oxy]-1H-benzimidazole-1-carboxylate (5.68 g, 13.9 mmol, STEP 1) and 20% palladium hydroxide (2.4 g) by the same manner in STEP 3 of Example 4.

Sources & evidence

ORD record
ord-60bc002a718d406f86b7ef342b7a572b
Source dataset
uspto-grants-2010_05
Patent number
US07723321B2

Reaction notes

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