4-Piperidinol, 1-methyl- → HCID 67244148, compound

HRID 2239607Notes

Reaction equation

HRID 2239607 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([OH:8])[CH2:4][CH2:3]1.[C:9]([O:13][C:14]([NH:16][CH2:17][CH2:18][C:19](O)=[O:20])=[O:15])([CH3:12])([CH3:11])[CH3:10].C(OC(NCCCC(OC1C(C)=CC=CC=1C)=O)=O)(C)(C)C>>[C:9]([O:13][C:14]([NH:16][CH2:17][CH2:18][C:19]([O:8][CH:5]1[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]1)=[O:20])=[O:15])([CH3:12])([CH3:11])[CH3:10]

Participants

4

Reactant 3

HCID 660484-Piperidinol, 1-methyl-HCID 76809N-((1,1-dimethylethoxy)carbonyl)-beta-alanineHCID 9138898HCID 9138898, compound

Product 1

HCID 67244148HCID 67244148, compound

Procedure

The title compound was prepared from 1-methylpiperidin-4-ol and N-(tert-butoxycarbonyl)-β-alanine in a similar manner as described for 2,6-dimethylphenyl 4-[(tert-butoxycarbonyl)amino]butanoate. 1H NMR (400 MHz, CDCl3): δ 4.99 (s, 1H), 4.74-4.79 (m, 1H), 3.32-3.6 (m, 2H), 2.58 (s, 2H), 2.45-2.49 (t, 2H), 2.23 (s, 3H), 2.16-2.19 (m, 2H), 1.83-1.88 (m, 2H), 1.62-1.71 (m, 2H), 1.34 (s, 9H).

Sources & evidence

ORD record
ord-f7c9b748d3c640e5ae32961409e091f0
Source dataset
uspto-grants-2010_05
Patent number
US07723333B2

Reaction notes

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