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0 °C

In a 40 ml reaction vial was added ethyl 1-(2-cyanoacetamido)-1H-imidazole-2-carboxylate (3.00 g, 13.50 mmol) prepared as described in (1b) and THF (2 ml). The mixture was cooled to 0° C. and potassium tert-butoxide (40.5 ml, 40.5 mmol) was added dropwise. The mixture was stirred at room temperature for 16 hours. 4.0 M HCl (10.13 ml, 40.5 mmol) in dioxane was added and the mixture was stirred for 30 min. The volatiles were evaporated to provide 6,8-dioxo-5,6,7,8-tetrahydroimidazo[1,2-b]pyridazine-7-carbonitrile which was used without purification in the following step. m/z=(177, M+1).

1. customIn a 40 ml reaction
2. customprepared
3. stirringthe mixture was stirred for 30 min
4. customThe volatiles were evaporated