反应详情

A mixture of para-nitrophenol (0.83 g, 6 mmoles), 1-bromo-4-chloro-butane (1.23 g, 7.2 mmoles), and K2CO3 (1.24 g, 9 mmoles) was stirred together in DMF at 80° C. for 1 hour. Reaction mixture was diluted with H2O, extracted with EtOAc, washed with water (2×), brine (1×), dried over Na2SO4, and concentrated under vacuum. The crude product was purified by HPLC using as eluent 30% EtOAc/hexane to afford the title compound as an off-white solid (1.28 g, 5.6 mmoles).

1. customReaction mixture
2. extractionextracted with EtOAc
3. washwashed with water (2×), brine (1×)
4. dry with materialdried over Na2SO4
5. concentrationconcentrated under vacuum
6. customThe crude product was purified by HPLC