Sodium borohydride → HCID 86610771, compound

HRID 2240090Notes

Reaction equation

HRID 2240090 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][CH:32]=1)[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[O:16])=[CH:12][CH:13]=2)[C:8]([S:17]([C:20]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:23]=[CH:22][CH:21]=2)(=[O:19])=[O:18])=[N:7]1.[BH4-].[Na+]>C1COCC1.O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][CH:32]=1)[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH2:15][OH:16])=[CH:12][CH:13]=2)[C:8]([S:17]([C:20]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:23]=[CH:22][CH:21]=2)(=[O:19])=[O:18])=[N:7]1

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 86610772HCID 86610772, compound

Product 1

HCID 86610771HCID 86610771, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

1-(3-Chloro-benzyl)-3-(naphthalene-1-sulfonyl)-1H-indazole-5-carbaldehyde (0.18 g, 0.4 mmol) was dissolved in THF and treated under nitrogen with the excess of sodium borohydride (0.2 mmol). After 1 hr the reaction mixture was diluted with water and the product extracted with methylene chloride to afford after evaporation of the solvent the title compound as a colorless solid (0.18 g, 0.4 mmoles).

Workup

  1. extractionthe product extracted with methylene chloride
  2. customto afford

Sources & evidence

ORD record
ord-1573997cf5c94fc8acebdf8a889d1c98
Source dataset
uspto-grants-2010_05
Patent number
US07723329B2

Reaction notes

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