Methane → HCID 178518411, compound

HRID 2240129Notes

Reaction equation

HRID 2240129 reaction equation
ClC1N=[C:4](NC2C=C(C=CC=2)C(O)=O)[C:5]2[S:10][CH2:9][CH2:8][C:6]=2N=1.[NH2:21][C:22]([NH2:24])=[O:23].C.[OH-:26].[Na+]>>[N:21]1[C:6]2[CH:8]=[CH:9][S:10][C:5]=2[C:4]([OH:26])=[N:24][C:22]=1[OH:23]

Participants

5

Reactant 4

HCID 297MethaneHCID 1176UreaHCID 14798Sodium HydroxideHCID 576001073-(2-Chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-ylamino)benzoic acid

Product 1

HCID 178518411HCID 178518411, compoundYield 75%

Procedure

10.0 g (64.0 mmol) of methylester 3-aminothiophene-2-carboxylate (I) and 19.0 g (31.60 mmol) of urea are mixed and melted for 2 hours at 200° C. After cooling, the reaction mixture is dissolved in 1 molar sodium hydroxide solution and decolorized with activated charcoal. It is filtered and the filtrate is cooled and acidified with 4M hydrochloric acid. The precipitate formed is suction filtered and dried. 8.03 g of product II (75%) is obtained as a powder.

Workup

  1. temperatureAfter cooling
  2. filtrationIt is filtered
  3. temperaturethe filtrate is cooled
  4. customThe precipitate formed
  5. filtrationfiltered
  6. customdried

Sources & evidence

ORD record
ord-d4842a8c06a9467096e454d1d8d95872
Source dataset
uspto-grants-2010_05
Patent number
US07723341B2

Reaction notes

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