Acetic Acid → HCID 57641202, compound

HRID 2240144Notes

Reaction equation

HRID 2240144 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[Cl:11][CH2:12][C:13](=[O:20])[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16].C(N)C1C=CC=CC=1.C(O)(=O)C>C(O)(C)C>[Cl:1][C:2]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:3]=1/[CH:4]=[C:14](/[C:13](=[O:20])[CH2:12][Cl:11])\[C:15]([O:17][CH2:18][CH3:19])=[O:16]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 7504BenzylamineHCID 134042,4-DichlorobenzaldehydeHCID 69484Ethyl 4-chloroacetoacetate

Product 1

HCID 57641202HCID 57641202, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

A solution 2,4-dichlorobenzaldehyde (4.6 g, 26.1 mmol), ethyl 4-chloro-3-oxobutanoate (4.5 g, 27.4 mmol), benzylamine (165 mg, 1.5 mmol), and acetic acid (118 mg, 2.0 mmol) in isopropyl alcohol (30 mL) stirred at ambient temperature for 96 h. The mixture was diluted with isopropyl alcohol to give a total volume of 50 mL and was saved as a stock solution of Example 1B (0.52 mmol/mL).

Workup

  1. customto give a total volume of 50 mL

Sources & evidence

ORD record
ord-9e18f7a23e2342ff94868dc912f282a5
Source dataset
uspto-grants-2010_05
Patent number
US07723355B2

Reaction notes

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