HCID 86610235, compound → HCID 11461462, compound

HRID 2240187Notes

Reaction equation

HRID 2240187 reaction equation
FC(F)(F)S(O[C:7]1[C:20]2[N:11]([C:12](=[O:30])[C:13]3[CH:14]=[CH:15][C:16]([O:28][CH3:29])=[CH:17][C:18]=3[C:19]=2[C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[CH:22]=2)[CH2:10][CH2:9][CH:8]=1)(=O)=O>CCO.CCOC(C)=O.O=[Pt]=O>[F:27][C:23]1[CH:22]=[C:21]([C:19]2[C:18]3[CH:17]=[C:16]([O:28][CH3:29])[CH:15]=[CH:14][C:13]=3[C:12](=[O:30])[N:11]3[CH2:10][CH2:9][CH2:8][CH2:7][C:20]=23)[CH:26]=[CH:25][CH:24]=1

Participants

5

Reactant 1

HCID 86610235HCID 86610235, compound

Product 1

HCID 11461462HCID 11461462, compound

Reagents, catalysts & solvents 3

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent2×HCID 8857Ethyl AcetateSolvent

Procedure

To a suspension of 11-(3-fluorophenyl)-9-methoxy-6-oxo-3,6-dihydro-4H-pyrido[1,2-b]isoquinolin-1-yl trifluoromethanesulfonate in EtOH (4 ml) and EtOAc (2 mL) was added PtO2 as a slurry in EtOH. The reaction was stirred at room temp under an H2 balloon for 16 h. The mixture was filtered through celite and concentrated. Flash chromatography (40 g silica, 30-80% EtOAc/hexanes) gave the titled compound.

Workup

  1. filtrationThe mixture was filtered through celite and
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-66ba0ac1ed5a431d980a47e1ba2e538d
Source dataset
uspto-grants-2010_05
Patent number
US07723352B2

Reaction notes

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