HCID 59304976, compound → 2-Fluoro-N1-(1-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzene-1,4-diamine

HRID 2240236Notes

Reaction equation

HRID 2240236 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[NH:11][C:12]1[C:13]2[CH:20]=[CH:19][N:18]([CH3:21])[C:14]=2[N:15]=[CH:16][CH:17]=1>C(O)C.C1COCC1.[Pt](=O)=O>[F:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[NH:11][C:12]1[CH:17]=[CH:16][N:15]=[C:14]2[N:18]([CH3:21])[CH:19]=[CH:20][C:13]=12

Participants

4

Reactant 1

HCID 59304976HCID 59304976, compound

Product 1

HCID 593050222-Fluoro-N1-(1-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzene-1,4-diamine

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 21873804Tetrahydrofuran ethanolSolvent

Procedure

195 mg (0.68 mmol) of N-(2-fluoro-4-nitrophenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine-4-amine are dissolved in 10 ml of a mixture of ethanol/THF. (1:1). 15 mg (0.07 mmol) of platinum(IV) oxide are added, and the mixture is stirred under a hydrogen atmosphere at atmospheric pressure overnight. The suspension is then filtered through Celite, the Celite is washed with a little ethanol and the solvent is removed under reduced pressure.

Workup

  1. filtrationThe suspension is then filtered through Celite
  2. washthe Celite is washed with a little ethanol
  3. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-ec2b02c0d36b49069b4e70a1ecfae85c
Source dataset
uspto-grants-2010_05
Patent number
US07723347B2

Reaction notes

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