反应详情

40 mg (0.15 mmol) of 3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)aniline and 29 mg (0.18 mmol) of 4,6-dichloropyrimidine-2-amine are suspended in 2 ml of water and 0.11 ml of 2N hydrochloric acid. The reaction mixture is heated at reflux for 15 hours. After cooling, the mixture is made alkaline using dilute aqueous sodium hydroxide solution, a little DMF is added and the mixture is extracted with ethyl acetate. The extract is dried over sodium sulfate and the solvent is removed under reduced pressure. The residue is purified by preparative HPLC.

1. temperatureThe reaction mixture is heated
2. temperatureat reflux for 15 hours
3. temperatureAfter cooling
4. extractionthe mixture is extracted with ethyl acetate
5. dry with materialThe extract is dried over sodium sulfate
6. customthe solvent is removed under reduced pressure
7. customThe residue is purified by preparative HPLC