Trifluoroacetic acid → spiro[indene-1,4'-piperidin]-3(2H)-one

HRID 2240396Notes

Reaction equation

HRID 2240396 reaction equation
CC(OC([N:8]1[CH2:13][CH2:12][C:11]2([C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[C:15](=[O:16])[CH2:14]2)[CH2:10][CH2:9]1)=O)(C)C.FC(F)(F)C(O)=O>>[NH:8]1[CH2:13][CH2:12][C:11]2([C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[C:15](=[O:16])[CH2:14]2)[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 18673579Tert-butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate

Product 1

HCID 18467061spiro[indene-1,4'-piperidin]-3(2H)-one

Procedure

N-boc-1-[4-spiro-piperidine]-3-indanone and trifluoroacetic acid were processed according to the method of Example 137D to provide the product. No purification was required. MS (ESI+) m/z 202 (M+H)+.

Workup

  1. customto provide the product
  2. customNo purification

Sources & evidence

ORD record
ord-5727a019f1ed40ef8146731beed4a457
Source dataset
uspto-grants-2010_05
Patent number
US07723367B2

Reaction notes

Loading…