Hydrochloric Acid → Benzenesulfonic Acid
Reaction equation
N([C:3]1[CH:8]=[CH:7][C:6]([S:9]([OH:12])(=[O:11])=[O:10])=[CH:5][CH:4]=1)N.Cl>>[C:6]1([S:9]([OH:12])(=[O:11])=[O:10])[CH:7]=[CH:8][CH:3]=[CH:4][CH:5]=1Participants
3
Procedure
Claisen reaction of the commercially available p-methyl-acetophenone and trifluoroacetic acid ethyl ester gave 4,4,4-trifluoro-1-(4-methylphenyl)-butane-1,3-dione in good yield. The latter was further reacted with the commercially available p-hydrazino-benzenesulfonic acid in an inert solvent in the presence of hydrochloric acid to give the new 4-(5-p-methyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl)-benzenesulfonic acid of formula (III) (yield over 80%),
Sources & evidence
- ORD record
- ord-aafbbfe4ad2049eaa45d888faa8f9bfc
- Source dataset
- uspto-grants-2010_05
- Patent number
- US07723370B2
Reaction notes
Loading…