Sodium Hydroxide → HCID 68480823, compound

HRID 2240555Notes

Reaction equation

HRID 2240555 reaction equation
[OH-].[Na+:2].ClC1C=CC(S(C2C3C(=CC=C(C)C=3)N(CC(O)=O)C=2C)(=O)=O)=CC=1.[Cl:28][C:29]1[C:30](C#N)=[C:31]2[C:35](=[CH:36][CH:37]=1)[N:34]([CH2:38][C:39]([O:41]C)=[O:40])[C:33]([CH3:43])=[C:32]2[S:44]([C:47]1[CH:52]=[CH:51][C:50]([Cl:53])=[CH:49][CH:48]=1)(=[O:46])=[O:45]>C1COCC1>[Cl:28][C:29]1[CH:30]=[C:31]2[C:35](=[CH:36][CH:37]=1)[N:34]([CH2:38][C:39]([O-:41])=[O:40])[C:33]([CH3:43])=[C:32]2[S:44]([C:47]1[CH:52]=[CH:51][C:50]([Cl:53])=[CH:49][CH:48]=1)(=[O:45])=[O:46].[Na+:2]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 104072752-[3-(4-chlorophenyl)sulfonyl-2,5-dimethylindol-1-yl]acetic acidHCID 86605157HCID 86605157, compound

Product 1

HCID 68480823HCID 68480823, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Sodium hydroxide (1M, 4.3 ml) was added to a solution of the product of example 1 part (c) (1.75 g) in THF (60 ml). The reaction mixture was stirred overnight and then concentrated in vacuo. The residue was recrystallised from water to give the title compound as a white solid.

Workup

  1. concentrationconcentrated in vacuo
  2. customThe residue was recrystallised from water

Sources & evidence

ORD record
ord-649e2d82c664437ca5b7fcb7cb8878f8
Source dataset
uspto-grants-2010_05
Patent number
US07723373B2

Reaction notes

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