Acetic Acid → HCID 86605158, compound

HRID 2240561Notes

Reaction equation

HRID 2240561 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH:11]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][C:18]=3[N+:20]([O-])=O)[NH:13][C:12]2([CH3:27])CC(O)=O)(=[O:10])=[O:9])=[CH:4][CH:3]=1.ClC1C(C#N)=C2C(=CC=1)N([CH2:38][C:39]([O:41][CH3:42])=[O:40])C(C)=C2S(C1C=CC(Cl)=CC=1)(=O)=O.[C:56](O)(=O)C>[Pt]>[NH2:20][C:18]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:19]=1[C:11]([S:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)(=[O:10])=[O:9])=[C:12]([CH3:27])[N:13]2[CH2:38][C:39]([O:41][CH2:42][CH3:56])=[O:40]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 68476972HCID 68476972, compoundHCID 86605157HCID 86605157, compound

Product 1

HCID 86605158HCID 86605158, compound

Reagents, catalysts & solvents 1

HCID 23939PlatinumCatalyst

Procedure

A suspension of the product from example 20 part (c) (1 g) in glacial acetic acid (50 ml) was stirred in the presence of 5% Pt/C (0.5 g) under 3 bar pressure of H2 for 24 hours. The catalyst was removed by filtration and the filtrates concentrated in vacuo. Purification by flash column chromatography (20% EtOAc/hexane as eluent) gave the subtitle compound (0.45 g).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrates concentrated in vacuo
  3. customPurification by flash column chromatography (20% EtOAc/hexane as eluent)

Sources & evidence

ORD record
ord-62d30d9c47024f2f973c8c75e89f10ee
Source dataset
uspto-grants-2010_05
Patent number
US07723373B2

Reaction notes

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