2-Aminopyridine → HCID 11325142, compound

HRID 2240597Notes

Reaction equation

HRID 2240597 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH2:7].[CH2:8]([N:15]1[CH2:20][CH2:19][CH:18]=[C:17]([CH2:21][CH2:22][C:23](O)=[O:24])[C:16]1=[O:26])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C(Cl)CCl>[CH2:8]([N:15]1[CH2:20][CH2:19][CH:18]=[C:17]([CH2:21][CH2:22][C:23]([NH:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)=[O:24])[C:16]1=[O:26])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 104392-AminopyridineHCID 11219135HCID 11219135, compound

Product 1

HCID 11325142HCID 11325142, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

Pyridyl amine was added to organic solvent dissolving 30 mg of 3-(1-benzyl-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl)-propionic acid (0.12 mM) in EDC. The resulting compound was purified by Silica gel column chromatography with methanol/chloroform (1:20) solvent mixture as an eluant to give 16 mg of the title compound (g1) (yield: 39%).

Workup

  1. customThe resulting compound was purified by Silica gel column chromatography with methanol/chloroform (1:20) solvent mixture as an eluant

Sources & evidence

ORD record
ord-b7abfa40421d4202ba8c5182d8c9bc45
Source dataset
uspto-grants-2010_05
Patent number
US07723376B2

Reaction notes

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