Lithium Hydroxide → HCID 11381185, compound

HRID 2240602Notes

Reaction equation

HRID 2240602 reaction equation
C[O:2][C:3](=[O:23])[CH2:4][C:5]1[C:6](=[O:22])[N:7]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:13]=2[O:20][CH3:21])[CH2:8][CH2:9][CH:10]=1.[Li+].[OH-]>C(O)(C(F)(F)F)=O>[CH3:21][O:20][C:13]1[CH:14]=[C:15]([O:18][CH3:19])[CH:16]=[CH:17][C:12]=1[CH2:11][N:7]1[CH2:8][CH2:9][CH:10]=[C:5]([CH2:4][C:3]([OH:23])=[O:2])[C:6]1=[O:22]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 57443431HCID 57443431, compound

Product 1

HCID 11381185HCID 11381185, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

[1-(2,4-dimethoxy-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-acetic acid methyl ester (o) prepared by the Step 2 of Example 26 dissolved in TFA was reacted with LiOH to give [1-(2,4-dimethoxy-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-acetic acid (q1).

Sources & evidence

ORD record
ord-d24c52793d9c43ee912551185cd0c5ec
Source dataset
uspto-grants-2010_05
Patent number
US07723376B2

Reaction notes

Loading…