Diethylamine → HCID 59305817, compound

HRID 2240649Notes

Reaction equation

HRID 2240649 reaction equation
C1C2C(COC(=O)[NH:17][CH:18]3[CH2:23][CH2:22][CH:21]([C:24]4[N:25]=[C:26]([CH3:29])[S:27][CH:28]=4)[CH2:20][CH2:19]3)C3C(=CC=CC=3)C=2C=CC=1.C(NCC)C>C1COCC1>[CH3:29][C:26]1[S:27][CH:28]=[C:24]([CH:21]2[CH2:22][CH2:23][CH:18]([NH2:17])[CH2:19][CH2:20]2)[N:25]=1

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 86643647HCID 86643647, compound

Product 1

HCID 59305817HCID 59305817, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.10 g (2 mmol) of 9H-fluoren-9-ylmethyl[4-(2-methylthiazol-4-yl)cyclohexyl]carbamate (cis compound) and 15 mL of diethylamine are stirred in 30 mL of THF for 16 hours at ambient temperature. Then the reaction mixture is concentrated by evaporation and the residue is combined with THF and concentrated again by evaporation. The residue is purified by chromatography. Yield: 0.13 g (36%).

Workup

  1. concentrationThen the reaction mixture is concentrated by evaporation
  2. concentrationconcentrated again by evaporation
  3. customThe residue is purified by chromatography

Sources & evidence

ORD record
ord-c726c598aa044a9db0ae54c40fa8732c
Source dataset
uspto-grants-2010_05
Patent number
US07723381B2

Reaction notes

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