Trimethylsilylacetylene → 2-Fluoro-5-((trimethylsilyl)ethynyl)benzonitrile

HRID 2240940Notes

Reaction equation

HRID 2240940 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:7](I)=[CH:6][C:3]=1[C:4]#[N:5].[C:11]([Si:13]([CH3:16])([CH3:15])[CH3:14])#[CH:12]>>[F:1][C:2]1[CH:9]=[CH:8][C:7]([C:12]#[C:11][Si:13]([CH3:16])([CH3:15])[CH3:14])=[CH:6][C:3]=1[C:4]#[N:5]

Participants

3

Reactant 2

HCID 66111TrimethylsilylacetyleneHCID 27789282-Fluoro-5-iodobenzonitrile

Product 1

HCID 593053312-Fluoro-5-((trimethylsilyl)ethynyl)benzonitrile

Procedure

The title compound was prepared in substantially the same manner as described in Example 1, step 3 starting from 2-Fluoro-5-iodo-benzonitrile (1.0 g, 4.14 mmol), and Ethynyl-trimethyl-silane (0.487 g, 4.97 mmol), and was obtained as a waxy brown solid, (0.90 g, 99%), identified by NMR and mass spectral analyses. MS (EI+): 216 (M+).

Workup

  1. customwas obtained as a waxy brown solid, (0.90 g, 99%),

Sources & evidence

ORD record
ord-a1a427deb8c743a482ff039798a14629
Source dataset
uspto-grants-2010_05
Patent number
US07723368B2

Reaction notes

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