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HRID2241103

反应详情

EQUATION

反应方程式

HRID 2241103 的结构方程式

REACTANTS

反应物

3
结构：Cc1ccc(S(=O)(=O)O)cc1
HCID6101

4-Methylbenzenesulfonic acid

C7H8O3S

结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：CC1(C)OCC(COC(=O)N2CCc3c(sc(NC(=O)/C=C/c4ccccc4)c3C#N)C2)O1
HCID59306305

未命名化合物

PRODUCTS

生成物

1
结构：N#Cc1c(NC(=O)/C=C/c2cccnc2)sc2c1CCN(C(=O)OCC(O)CO)C2
HCID59306436

未命名化合物

收率 80%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)C#N.O
溶剂HCID131723227

未命名化合物

PROCEDURE

实验过程

0.26 mmol of 3-Cyano-2-((E)-3-phenyl-allanoylamino)-4,7-dihydro-5H-thieno[2,3-c]pyridine-6-carboxylic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester are dissolved in 10 ml AcCN/H2O (2/1) and 0.1 eq PTSA is added. After stirring over night, some triethylamine is added and the solvent removed. Recrystallization from ethanol gives the desired product in 80% yield.

WORKUP

后处理

  1. customthe solvent removed
  2. customRecrystallization from ethanol