反应详情

温度

40 °C

100 g of the free base was dissolved in 250 mL of 2-propanol. 1 eq. of oxalic acid dihydrate was dissolved in 250 mL of warm 2-propanol and was added at 40° C. to the solution of escitalopram base. After stirring at 40° C. for 10 min the crystallization started. The mixture was then allowed to cool to room temperature and stirred for ca. 2 hours. The crystals were filtered off, rinsed on the filter with 2-propanol and dried to constant weight under vacuum at 60° C.

1. customthe crystallization
2. temperatureto cool to room temperature
3. stirringstirred for ca. 2 hours
4. filtrationThe crystals were filtered off
5. washrinsed on the
6. filtrationfilter with 2-propanol
7. customdried to constant weight under vacuum at 60° C.